The American will regain the world number one ranking from Russian Maria Sharapova if she reaches the final.
The Indian challenge ended at the Roger Cup after Leander Paes and Radek Stepanek suffered a second-round defeat at the hands of Andy Murray and Colin Fleming in Montreal.
Mirza teamed up with Russian Anna Chakvetadze to beat Kristina Brandi of Puerto Rico and Nana Miyagi of Japan.
The Indian pair was beaten by Zi Yan and Jie Zheng in the quarter-finals at the Hyderabad Open.
Jie Zheng beat Rushmi Chakravarthi 6-3, 6-0 and Na Li tamed Shikha Uberoi 6-1, 6-2 to give China a 2-0 lead.
Sania Mirza continued her impressive run as she captured her fourth title of the season and 18th overall with Cara Black of Zimbabwe, recording a come-from-behind win over Liezel Huber and Hao Ching Chan to lift the Pan Pacific Open trophy in Tokyo.
Sania Mirza has received another lift in her already booming career. The Indian tennis ace reached the 25th doubles final of her career at the WTA New Haven Open.
India's Sania Mirza and her partner Cara Black of Zimbabwe could not make it to the US Open women's doubles finals after going down in straight sets to Swiss-Italian pair of Martina Hingis and Flavia Pennetta at the Flushing Meadows.
Leander Paes will kickstart his US Open campaign with Czech partner Radek Stepanek against Jarkko Nieminen of Finland and Dmitry Tursunov of Russia.
India's Sania Mirza and Zimbabwe's Cara Black entered the final of the WTA China Open, shocking top seeds Sara Errani and Roberta Vinci of Italy 6-4, 6-4 on Friday. In doing do they extended their unbeaten run to eight matches, and Sania put herself in line for her fifth title of the season.
Leander Paes and Canada's Daniel Nestor beat the Spanish combination of Fernando Verdasco and David Marrero 7-6(10-8), 6-3 in 83 minutes, while Sania Mirza and her Zimbabwean partner Cara Black beat Chinese Taipei's Yung-Jan Chan and Jie Zheng.
PHOTOS from day seven of the Wimbledon championships at the All England Lawn Tennis in London on Tuesday.
Indian tennis players enjoyed an all-win day at the US Open as three of them reached the men's doubles third round with their respective partners, while Sania Mirza entered the women's doubles pre-quarters.
Millions of people worldwide are having to embrace life under lockdown -- confined to their own four walls or neighbourhoods for weeks on end as countries battle to reduce the spread of the coronavirus.